Pinealon

Pinealon

Catalog strength: 10mg/3ml

Research Overview

Overview: Pinealon (Glu-Asp-Arg) is a synthetic tripeptide (L-glutamic acid, L-aspartic acid, L-arginine) described in scientific literature as a peptide bioregulator. Research indicates that Pinealon can cross cellular and nuclear membranes, enabling interaction with DNA and modulation of gene expression in experimental systems. These properties have made it a subject of investigation in studies examining cellular stress responses, oxidative pathways, and apoptosis signaling. Mechanism of Action (Describes mechanisms observed in published research – NOT effects of this product.) Modulates MAPK/ERK signaling pathways in experimental models. Enhances expression of antioxidant enzymes such as SOD2 and GPX1. Regulates transcription factors involved in oxidative stress responses (PPARA, PPARG) and apoptotic proteins (e.g., caspase-3). Tissue Specificity (Research Context) Nervous System: Studied for neuroprotective and cognitive signaling pathways. Systemic Models: Investigated for antioxidant and anti-inflammatory effects at the cellular level.

Research Findings

Oxidative Stress Models: Pinealon reduced reactive oxygen species (ROS) accumulation and mitigated hypoxic cell death in experimental systems (Arutjunyan et al., 2012).

Cognitive Signaling: Research reports improvements in spatial learning and memory performance in rodent models undergoing chronic stress (Meshchaninov et al., 2015).

Excitotoxicity Resistance: Studies show increased neuronal survival during oxygen deprivation or elevated glutamate exposure.

Apoptosis Pathways: Modulated caspase-3 expression and reduced signals associated with programmed cell death.

Circadian Studies: Associated with stabilization of sleep-wake gene expression patterns in research animals.

Telomere-related Pathways: Increased irisin expression, which correlates with telomere-associated biomarkers.

Inflammatory Signaling: Downregulated pro-inflammatory cytokines in cellular models.

Traumatic Brain Injury (TBI) Models: Experimental data show enhanced cognitive performance after TBI in rodent systems.

CAS number: 307950-60-3

Molar mass: 432.44 g/mol

RESEARCH USE ONLY – NOT FOR HUMAN OR VETERINARY USE.

This product is offered strictly as a laboratory research material for qualified researchers and educational or analytical use. It is not a drug, food, dietary supplement, cosmetic, medical device, or consumer product. It is not intended for ingestion, injection, inhalation, topical application, compounding, prescribing, dispensing, administration, or any other use in humans or animals.

This product has not been approved by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, mitigate, or prevent any disease or medical condition. Statements describing mechanisms, pathways, observations, or potential benefits summarize the research context presented in the source catalog and do not constitute medical advice, therapeutic claims, instructions for use, or evidence of safety or efficacy in humans.

The purchaser is solely responsible for verifying that acquisition, possession, handling, storage, research, transfer, and disposal comply with all applicable federal, state, and local laws, institutional requirements, and laboratory safety standards. Sale may be restricted to appropriately qualified research entities. By purchasing, the purchaser represents that the material will be used only for lawful, non-clinical research and will not be resold or supplied for human or veterinary administration.